Journal article

Macrophages and microglia produce local trophic gradients that stimulate axonal sprouting toward but not beyond the wound edge

PE Batchelor, MJ Porritt, P Martinello, CL Parish, GT Liberatore, GA Donnan, DW Howells

MOLECULAR AND CELLULAR NEUROSCIENCE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2002

Abstract

Following injury to the mammalian CNS, axons sprout in the vicinity of the wound margin. Growth then ceases and axons fail to cross the lesion site. In this study, using dopaminergic sprouting in the injured striatum as a model system, we have examined the relationship of periwound sprouting fibers to reactive glia and macrophages. In the first week after injury we find that sprouting fibers form intimate relationships with activated microglia as they traverse toward the wound edge. Once at the wound edge, complicated plexuses of fibers form around individual macrophages. Axons, however, fail to grow further into the interior of the wound despite the presence of many macrophages in this loca..

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