Journal article

A Genome-Wide Association Study Identifies Novel and Functionally Related Susceptibility Loci for Kawasaki Disease

David Burgner, Sonia Davila, Willemijn B Breunis, Sarah B Ng, Yi Li, Carine Bonnard, Ling Ling, Victoria J Wright, Anbupalam Thalamuthu, Miranda Odam, Chisato Shimizu, Jane C Burns, Michael Levin, Taco W Kuijpers, Martin L Hibberd



Kawasaki disease (KD) is a pediatric vasculitis that damages the coronary arteries in 25% of untreated and approximately 5% of treated children. Epidemiologic data suggest that KD is triggered by unidentified infection(s) in genetically susceptible children. To investigate genetic determinants of KD susceptibility, we performed a genome-wide association study (GWAS) in 119 Caucasian KD cases and 135 matched controls with stringent correction for possible admixture, followed by replication in an independent cohort and subsequent fine-mapping, for a total of 893 KD cases plus population and family controls. Significant associations of 40 SNPs and six haplotypes, identifying 31 genes, were repl..

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Awarded by Heart, Lung, Blood Institute of the National Institutes of Health, Bethesda, MD, USA

Awarded by Netherlands Genomic Initiative (NROG)

Awarded by ZonMw

Awarded by STINAFO

Funding Acknowledgements

This work was supported in part by the following grants and funding agencies: Sir Samuel Scott of Yews Trust, The London Law Trust, Princess Margaret Hospital, Raine Medical Research Foundation, Ada Bartholomew Medical Research Trust, University of Western Australia, National Heart Foundation of Australia, Heart, Lung, Blood Institute of the National Institutes of Health, Bethesda, MD, USA, (Grant #HL69413 to JCB), Agency for Science & Technology and Research of Singapore (A*STAR). TK and WB were supported by grants from the Netherlands Genomic Initiative (NROG, 050-71-315), by ZonMw (920-03-391) and STINAFO (2008051). The funding agencies had no role in the design, conduct and analysis of the study.