An Insight into the Relationships between Hepcidin, Anemia, Infections and Inflammatory Cytokines in Pediatric Refugees: A Cross-Sectional Study
Sarah Cherian, David A Forbes, Angus G Cook, Frank M Sanfilippo, Erwin H Kemna, Dorine W Swinkels, David P Burgner
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2008
BACKGROUND: Hepcidin, a key regulator of iron homeostasis, is increased in response to inflammation and some infections, but the in vivo role of hepcidin, particularly in children with iron deficiency anemia (IDA) is unclear. We investigated the relationships between hepcidin, cytokines and iron status in a pediatric population with a high prevalence of both anemia and co-morbid infections. METHODOLOGY/PRINCIPAL FINDINGS: African refugee children <16 years were consecutively recruited at the initial post-resettlement health check with 181 children meeting inclusion criteria. Data on hematological parameters, cytokine levels and co-morbid infections (Helicobacter pylori, helminth and malaria)..View full abstract
SC received a 2007 University of Western Australia Research Grant, a 2007 Royal Australasian College of Physicians Grant and a 2007 Princess Margaret Foundation Seeding Grant for laboratory assays and consumables.Faecal antigen kits were supplied by Dako, Denmark and Oxoid, Australia to the investigating team without charge or with any other provision of research funding. Neither company had any input or influence into the study design, data collection and analysis, interpretation, decision to publish or preparation of this manuscript.