Redox mechanisms of the beneficial effects of heme oxygenase in hypertension
Elsa C Chan, Gregory J Dusting, Guei-Sheung Liu, Fan Jiang
Journal of Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
Heme oxygenases, namely heme oxygenase-1 and heme oxygenase-2, have important biological functions in vascular homeostasis. Heme oxygenase and its catabolic products, including bilirubin and carbon monoxide, have been implicated in blood pressure regulation. Increased expression of heme oxygenase exerts multiple protective actions against hypertension-induced vascular injuries. However, the underlining mechanisms of these effects are not entirely clear. We and others have demonstrated that heme oxygenase-1 can modulate production of reactive oxygen species, both in vivo and in vitro, from NADPH oxidase, a major enzymatic source of reactive oxygen species generation in the vascular wall. NADP..View full abstract
Awarded by National 973 Basic Research Program
Awarded by Natural Science Foundation of China
E.C.C. and G.S.L. are supported by The Ansell Ophthalmology Foundation. G.J.D. is an NHMRC Principal Research Fellow. F.J. is supported by grants from National 973 Basic Research Program (2010CB732605) and Natural Science Foundation of China (#81271269). Centre for Eye Research Australia acknowledges the Victorian State Government's Department of Innovation, Industry and Regional Development's Operational Infrastructure Support Program.