Journal article

Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice

D Moneta, C Richichi, M Aliprandi, P Dournaud, P Dutar, JM Billard, AS Carlo, C Viollet, JP Hannon, D Fehlmann, C Nunn, D Hoyer, J Epelbaum, A Vezzani

European Journal of Neuroscience | BLACKWELL PUBLISHING LTD | Published : 2002

Abstract

We have investigated the role of somatostatin receptor subtypes sst2 and sst4 in limbic seizures and glutamate-mediated neurotransmission in mouse hippocampus. As compared to wild-type littermates, homozygous mice lacking sst2 receptors showed a 52% reduction in EEG ictal activity induced by intrahippocampal injection of 30 ng kainic acid (P < 0.05). The number of behavioural tonic-clonic seizures was reduced by 50% (P < 0.01) and the time to onset of seizures was doubled on average (P < 0.05). Seizure-associated neurodegeneration was found in the injected hippocampus (CA1, CA3 and hilar interneurons) and sporadically in the ipsilateral latero-dorsal thalamus. This occurred to a similar exte..

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