Conference Proceedings

Effects of the ECE/NEP inhibitor CGS 34225 on the big ET-1-induced pressor response and plasma atrial natriuretic peptide concentration in conscious rats

AJ Trapani, ME Beil, CW Bruseo, CA Fink, D Hoyer, P Savage, AY Jeng

Clinical Science | PORTLAND PRESS | Published : 2002

DOI: 10.1042/CS103S102S

University of Melbourne Researchers

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Keywords

Inhibitory Concentration 50
Pharmacology
Neprilysin
Endothelin-Converting Enzymes
Omapatrilat
Endothelin-1
Blood Pressure
Cgs 34225
Life Sciences & Biomedicine
Research & Experimental Medicine
Male
Endothelin-Converting Enzyme-1
Heart-Failure
Neutral Endopeptidase Inhibitor
Aspartic Acid Endopeptidases
Endothelins
Endothelin Converting Enzyme
Metalloendopeptidases
Rats, Sprague-Dawley
Enzyme Inhibitors
Essential-Hypertension
Animals
Peptide Fragments
Rats
Protein Precursors
Atrial Natriuretic Peptide
Neutral Endopeptidase 24.11
Design
Big Endothelin-1 Pressor Response
Atrial Natriuretic Factor
Dual Ece/nep Inhibitor
Sulfhydryl Compounds
Dose-Response Relationship, Drug
Science & Technology
Medicine, Research & Experimental
Phenylalanine
Blood-Pressure
Lisinopril
Area Under Curve
Vasopeptidase Inhibitor