Journal article

A diffusion tensor imaging study of fasciculi in schizophrenia

Sukhwinder S Shergill, Richard A Kanaan, Xavier A Chitnis, Owen O'Daly, Derek K Jones, Sophia Frangou, Steven CR Williams, Robert J Howard, Gareth J Barker, Robin M Murray, Philip McGuire

American Journal of Psychiatry | AMER PSYCHIATRIC PUBLISHING, INC | Published : 2007


OBJECTIVE: Cognitive models propose that the symptoms and psychological impairments associated with schizophrenia arise as a consequence of impaired communication between brain regions, especially the prefrontal cortex and the temporal and parietal lobes. Functional imaging and electrophysiological data have provided evidence of functional dysconnectivity, but it is unclear whether this reflects an underlying problem with anatomical connectivity. This study used diffusion tensor imaging to examine the integrity of the major white matter fasciculi, which connects the frontal and temporal-parietal cortices, and the corpus callosum in patients with schizophrenia. METHOD: A 1.5-T magnetic resona..

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