Journal article

Effect of sustained viral response on hepatic venous pressure gradient in hepatitis C-related cirrhosis

Stuart Roberts, Adam Gordon, Catriona McLean, John Pedersen, Scott Bowden, Kenneth Thomson, Peter Angus

Clinical Gastroenterology and Hepatology | ELSEVIER SCIENCE INC | Published : 2007

Abstract

BACKGROUND & AIMS: Interferon-based therapy can improve hepatic histology in chronic hepatitis C (CHC)-related cirrhosis but its effect on portal hypertension is unclear. The aims of this study were to investigate the effect of treatment with peginterferon alfa-2a and ribavirin on hepatic venous pressure gradient (HVPG) in CHC with compensated cirrhosis. METHODS: Forty-seven patients with compensated biopsy examination-proven cirrhosis were recruited from 2 metropolitan teaching hospitals and were treated for 48 weeks with combination peginterferon alfa-2a 180 microg by subcutaneous injection weekly and ribavirin 800-1200 mg/day orally. A transjugular liver biopsy examination and HVPG measur..

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