Journal article
The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: Evidence from mice and humans
M Sashindranath, E Sales, M Daglas, R Freeman, AL Samson, EJ Cops, S Beckham, A Galle, C McLean, C Morganti-Kossmann, JV Rosenfeld, R Madani, JD Vassalli, EJ Su, DA Lawrence, RL Medcalf
Brain | OXFORD UNIV PRESS | Published : 2012
DOI: 10.1093/brain/aws178
Abstract
The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in numerous brain pathologies including neurotrauma and ischaemic stroke. Tissue plasminogen activator is a serine protease that converts plasminogen to plasmin, a protease that dissolves blood clots. Besides its role in fibrinolysis, tissue plasminogen activator is abundantly expressed in the brain where it mediates extracellular proteolysis. However, proteolytically active tissue plasminogen activator also promotes neurovascular disruption after ischaemic stroke; the molecular mechanisms of this process are still unclear. Tissue plasminogen ac..
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Awarded by National Institutes of Health
Funding Acknowledgements
Grant numbers 606660 and D0-34 awarded to R.L.M from the National Health and Medical Research Council (NHMRC) of Australia and the Victorian Neurotrauma Initiative, respectively, and by grant numbers HL55374, HL54710, and HL089407 awarded to D. A. L from the National Institutes of Health. Tissues were received from the Neurotrauma Tissue/Fluid Bank, supported by the Victorian Brain Bank Network, Mental Health Research Institute, The Alfred Hospital, the National Trauma Research Institute, Victorian Forensic Institute of Medicine and funded by Victorian Neurotrauma Initiative, the Transport Accident Commission (TAC) and the NHMRC of Australia.