Journal article
Influence of single nucleotide polymorphisms in COMT, MAO-A and BDNF genes on dyskinesias and levodopa use in Parkinson's disease
P Cheshire, K Bertram, H Ling, SS O'Sullivan, G Halliday, C McLean, J Bras, T Foltynie, E Storey, DR Williams
Neurodegenerative Diseases | KARGER | Published : 2013
DOI: 10.1159/000351097
Abstract
Background: Clinical heterogeneity in the development of levodopa-induced dyskinesias (LID) suggests endogenous factors play a significant role in determining their overall prevalence. Objective: We hypothesised that single nucleotide polymorphisms (SNPs) in specific genes may result in a clinical phenotype conducive to an increased risk of LID. Methods: We examined the influence of SNPs in the catechol-O-methyltransferase (COMT), monoamine oxidase A (MAO-A) and brain-derived neurotrophic factor (BDNF) genes on LID in a cohort of 285 pathologically confirmed Parkinson's disease patients, using data from their complete disease course. Results: Dyskinetic patients demonstrated younger age at d..
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Awarded by University of New South Wales
Funding Acknowledgements
We would like to thank Catherine Smith, Monash University, for her assistance with statistical modelling and Linda Parsons, QSBB, for her assistance with tissue acquisition. We thank brain donors and their families, without whom this work would not have been possible. This work was funded by the Bethlehem Griffiths Research Foundation, the Brain Foundation, the Wellcome Trust (WTCCC2, grants 084747 and 083948) and Parkinson's UK (K-0901). This work was partly undertaken at UCLH/UCL who received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres funding scheme. Support was also received from the Wellcome Trust/MRC Joint Call in Neurodegeneration Award (WT089698) to UCL, the MRC Unit in Dundee and the University of Sheffield. The ABBN is supported by Neuroscience Research Australia, the University of New South Wales and the National Health and Medical Research Council of Australia.