Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: Analysis from the PREDICT and CHARIOT studies
Stuart K Roberts, Joanne Mitchell, Reynold Leung, David Booth, Steven Bollipo, George Ostapowicz, Andrew Sloss, Geoffrey W McCaughan, Gregory J Dore, Alexander Thompson, Darrell HG Crawford, William Sievert, Martin Weltman, Wendy Cheng, Jacob George
Journal of Gastroenterology and Hepatology | WILEY | Published : 2014
BACKGROUND AND AIMS: The aim of this study was to examine the distribution of interferon lambda-3 (IFN-λ3) gene polymorphisms in previously untreated Australian patients with genotype 1 (Gt1) chronic hepatitis C (CHC) and to compare the IFN-λ3 genotype frequency among the different ethnic populations. METHODS: This was a prospective, multicenter, observational study undertaken by the Australian Liver Association Clinical Research Network. Eligible subjects had Gt1 CHC and were being considered for and/or undergoing treatment. IFN-λ3 single nucleotide polymorphisms were genotyped by the Applied Biosystems's Taqman single nucleotide polymorphism genotyping assay. RESULTS: Between May 2012 and ..View full abstract
The Authors acknowledge the support of all the members of the ALA CRN including principal investigators and nursing coordinators who contributed to timely patient recruitment in the PREDICT study. Both the PREDICT and CHARIOT studies were sponsored by financial grants received by Roche Australia.