Journal article

Homeostatic control of regulatory T cell diversity

Adrian Liston, Daniel HD Gray

NATURE REVIEWS IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2014

Abstract

Regulatory T (TReg) cells constitute an essential counterbalance to adaptive immune responses. Failure to maintain appropriate TReg cell numbers or function leads to autoimmune, malignant and immunodeficient conditions. Dynamic homeostatic processes preserve the number of forkhead box P3-expressing (FOXP3(+)) TReg cells within a healthy range, with high rates of cell division being offset by apoptosis under steady-state conditions. Recent studies have shown that TReg cells become specialized for different environmental contexts, tailoring their functions and homeostatic properties to a wide range of tissues and immune conditions. In this Review, we describe new insights into the molecular co..

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University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council


Funding Acknowledgements

The authors apologize to any colleagues whose work they were unable to cite owing to space constraints. The authors thank the members of their laboratories for their input. A.L. is funded by the European Research Council, Juvenile Diabetes Research Foundation and VIB. D.H.D.G. is funded by an Australian National Health and Medical Research Council Career Development Fellowship (637535) and Project Grant (1049724).