Journal article

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

LE Dow, IA Elsum, CL King, KM Kinross, HE Richardson, PO Humbert

Oncogene | NATURE PUBLISHING GROUP | Published : 2008

Abstract

Activating mutations in genes of the Ras-mitogen-activated protein kinase (MAPK) pathway occur in approximately 30% of all human cancers; however, mutation of Ras alone is rarely sufficient to induce tumour development. Scribble is a polarity regulator recently isolated from a Drosophila screen for events that cooperate with Ras mutation to promote tumour progression and cell invasion. In mammals, Scribble regulates directed cell migration and wound healing in vivo; however, no role has been identified for mammalian Scribble in oncogenic transformation. Here we show that in human epithelial cells expressing oncogenic Ras or Raf, loss of Scribble promotes invasion of cells through extracellul..

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