Journal article

Role of toll-like receptors in liver transplantation

Jessica Howell, Paul Gow, Peter Angus, Kumar Visvanathan

Liver Transplantation | WILEY-BLACKWELL | Published : 2014

Abstract

Toll-like receptors (TLRs) are pathogen recognition receptors that orchestrate the innate immune response and the subsequent adaptive immune response. TLRs can be triggered by exogenous ligands expressed by invading pathogens or by the release of endogenous ligands, such as that occurring through cellular injury during the transplantation process. They are now recognized to play an important role in many facets of transplantation biology, including rejection and tolerance, ischemia/reperfusion injury (IRI), and infections after transplantation. The role of TLRs in liver transplantation is unique with respect to other organ transplants because the portal circulation is a continuous source of ..

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