Journal article

Tissue dendritic cells as portals for HIV entry

Andrew N Harman, Min Kim, Najla Nasr, Kerrie J Sandgren, Paul U Cameron

Reviews in Medical Virology | WILEY | Published : 2013


Dendritic cells (DCs) are found at the portals of pathogen entry such as the mucosal surfaces of the respiratory, gastrointestinal and genital tracts where they represent the first line of contact between the immune system and the foreign invaders. They are found throughout the body in multiple subsets where they express unique combinations of C-type lectin receptors to best aid them in detection of pathogens associated with their anatomical location. DCs are important in the establishment in HIV infection for two reasons. Firstly, they are one of the first cells to encounter the virus, and the specific interaction that occurs between these cells and HIV is critical to HIV establishing a foo..

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University of Melbourne Researchers