CD154( ) CD4( ) T-cell dependence for effective memory influenza virus-specific CD8( ) T-cell responses
Matthew R Olson, Shirley GK Seah, Kathryn Edenborough, Peter C Doherty, Andrew M Lew, Stephen J Turner
Immunology and Cell Biology | NATURE PUBLISHING GROUP | Published : 2014
CD40-CD154 (CD40 ligand) interactions are essential for the efficient priming of CD8(+) cytotoxic T lymphocyte (CTL) responses. This is typically via CD4(+)CD154(+) T-cell-dependent 'licensing' of CD40(+) dendritic cells (DCs); however, DCs infected with influenza A virus (IAV) upregulate CD154 expression, thus enabling efficient CTL priming in the absence of CD4(+) T activation. Therefore, it is unclear whether CD4 T cells and DCs have redundant or unique roles in the priming of primary and secondary CTL responses after infection. Here we determine the precise cellular interactions involved in CD40-CD154 regulation of both primary and secondary IAV-specific CTL responses. Infection of both ..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC) program
Awarded by NMHRC project
Awarded by Juvenile Diabetes Research Foundation
We thank Drs Bridie Day and Brendan Russ for critical review of this manuscript. This work was supported by Australian National Health and Medical Research Council (NHMRC) program grant 5671222 (PCD and SJT) and 1037321 (AML), an NMHRC project grant 1043414 (AML), Juvenile Diabetes Research Foundation grant 112613, Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIIS, DSO National Laboratories Scholarship, Singapore (SGKS), and an Australian Research Council Future Fellowship (SJT).