Journal article

Short-Term Intensified Cycle Training Alters Acute and Chronic Responses of PGC1 alpha and Cytochrome C Oxidase IV to Exercise in Human Skeletal Muscle

Nigel K Stepto, Boubacar Benziane, Glenn D Wadley, Alexander V Chibalin, Benedict J Canny, Nir Eynon, Glenn K McConell

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2012


Reduced activation of exercise responsive signalling pathways have been reported in response to acute exercise after training; however little is known about the adaptive responses of the mitochondria. Accordingly, we investigated changes in mitochondrial gene expression and protein abundance in response to the same acute exercise before and after 10-d of intensive cycle training. Nine untrained, healthy participants (mean±SD; VO(2peak) 44.1±17.6 ml/kg/min) performed a 60 min bout of cycling exercise at 164±18 W (72% of pre-training VO(2peak)). Muscle biopsies were obtained from the vastus lateralis muscle at rest, immediately and 3 h after exercise. The participants then underwent 10-d of cy..

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University of Melbourne Researchers


Awarded by commission of the European Communities

Funding Acknowledgements

This work was supported by grants from the Swedish Research Council, the Novo-Nordisk Foundation, and the commission of the European Communities (Contract number LSHM-CT-2004-512013 EUGENEHEART and Contract No. LSHM-CT-2004-005272 EXGENESIS)to AVC. NKS is supported by the Australian Government Collaborative Research Network Scheme. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.