Exercise as an intervention to improve metabolic outcomes after intrauterine growth restriction
Kathryn L Gatford, Gunveen Kaur, Filippe Falcao-Tebas, Glenn D Wadley, Mary E Wlodek, Rhianna C Laker, Peter R Ebeling, Glenn K McConell
American Journal of Physiology - Endocrinology and Metabolism | AMER PHYSIOLOGICAL SOC | Published : 2014
Individuals born after intrauterine growth restriction (IUGR) are at an increased risk of developing diabetes in their adult life. IUGR impairs β-cell function and reduces β-cell mass, thereby diminishing insulin secretion. IUGR also induces insulin resistance, with impaired insulin signaling in muscle in adult humans who were small for gestational age (SGA) and in rodent models of IUGR. There is epidemiological evidence in humans that exercise in adults can reduce the risk of metabolic disease following IUGR. However, it is not clear whether adult IUGR individuals benefit to the same extent from exercise as do normal-birth-weight individuals, as our rat studies suggest less of a benefit in ..View full abstract
We acknowledge funding from the National Health and Medical Research Council of Australia (NHMRC) and Commonwealth Government of Australia Collaborative Research Network (CRN).