The importance of regulatory RNAs in Staphylococcus aureus
Arnaud Tomasini, Patrice Francois, Benjamin P Howden, Pierre Fechter, Pascale Romby, Isabelle Caldelari
Infection Genetics and Evolution | ELSEVIER SCIENCE BV | Published : 2014
RNA molecules with regulatory functions in pathogenic bacteria have benefited from a renewed interest these two last decades. In Staphylococcus aureus, recent genome-wide approaches have led to the discovery that almost 10-20% of genes code for RNAs with critical regulatory roles in adaptive processes. These RNAs include trans-acting RNAs, which mostly act through binding to target mRNAs, and cis-acting RNAs, which include regulatory regions of mRNAs responding to various metabolic signals. Besides recent analysis of S. aureus transcriptome has revealed an unprecedented existence of pervasive transcription generating a high number of weakly expressed antisense RNAs along the genome as well a..View full abstract
Awarded by Agence Nationale de la Recherche and the "Laboratoires d'excellence" (LABEX) NetRNA
We are thankful to all other members of the team for helpful comments on the manuscript. We are grateful to Francois Vandenesch and to Thomas Geissmann (University of Lyon, INSERM) for helpful discussions and support. This work was supported by the Centre National de la Recherche Scientifique (CNRS, PR), the Agence Nationale de la Recherche and the "Laboratoires d'excellence" (LABEX) NetRNA Grant ANR-10-LABX-36 (PR) in the frame of "Programme d'Investissements d'Avenir", and the National Health and Medical Research Council (NHMRC), Australia (BPH).