Porphyromonas gingivalis Peptidylarginine Deiminase, a Key Contributor in the Pathogenesis of Experimental Periodontal Disease and Experimental Arthritis
Neville Gully, Richard Bright, Victor Marino, Ceilidh Marchant, Melissa Cantley, David Haynes, Catherine Butler, Stuart Dashper, Eric Reynolds, Mark Bartold
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2014
OBJECTIVES: To investigate the suggested role of Porphyromonas gingivalis peptidylarginine deiminase (PAD) in the relationship between the aetiology of periodontal disease and experimentally induced arthritis and the possible association between these two conditions. METHODS: A genetically modified PAD-deficient strain of P. gingivalis W50 was produced. The effect of this strain, compared to the wild type, in an established murine model for experimental periodontitis and experimental arthritis was assessed. Experimental periodontitis was induced following oral inoculation with the PAD-deficient and wild type strains of P. gingivalis. Experimental arthritis was induced via the collagen antibo..View full abstract
Awarded by Australian Dental Research Fund
Awarded by National Health & Medical Council of Australia
This study was supported in part by research grants from the Australian Dental Research Fund (ADRF 56/2010) and the National Health & Medical Council of Australia (NHMRC 1023747). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.