Journal article

Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4 T cells from children with IgE-mediated food allergy

David Martino, Jihoon E Joo, Alexandra Sexton-Oates, Thanh Dang, Katrina Allen, Richard Saffery, Susan Prescott

Epigenetics | TAYLOR & FRANCIS INC | Published : 2014

Abstract

UNLABELLED: Food allergy is mediated by a combination of genetic and environmental risk factors, potentially mediated by epigenetic mechanisms. CD4+ T-cells are key drivers of the allergic response, and may therefore harbor epigenetic variation in association with the disease phenotype. Here we retrospectively examined genome-wide DNA methylation profiles (~450,000 CpGs) from CD4+ T-cells on a birth cohort of 12 children with IgE-mediated food allergy diagnosed at 12-months, and 12 non-allergic controls. DNA samples were available at two time points, birth and 12-months. CASE: control comparisons of CD4+ methylation profiles identified 179 differentially methylated probes (DMP) at 12-months ..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by CASS foundation


Awarded by NHMRC Centre of Food and Allergy Research Excellence


Funding Acknowledgements

This work was funded by the National Health and Medical Research Council of Australia (APP10002381), the CASS foundation (SM/11/3647/RMR:DSA), NHMRC Centre of Food and Allergy Research Excellence (#1041420).