Journal article

Differential Patterns of Planning Impairments in Parkinson's Disease and Sub-Clinical Signs of Dementia? A Latent-Class Model-Based Approach

Lena Koestering, Audrey McKinlay, Christoph Stahl, Christoph P Kaller

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2012

Abstract

Planning impairments mark a well-documented consequence of neurodegenerative diseases such as Parkinson's disease (PD). Recently, using the Tower of London task we demonstrated that, rather than being generally impaired, PD patients selectively fail when planning requires flexible in-breadth search strategies. For a better understanding of the interindividual patterns underlying specific planning impairments, here we performed an explorative re-analysis of the original data using a latent-class model-based approach. Data-driven classification according to subjects' performance was based on a multinomial processing tree (MPT) model accommodating the impact of increased breadth versus depth of..

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Grants

Awarded by German Federal Ministry of Education and Research (BMBF)


Funding Acknowledgements

Christoph Kaller and Christoph Stahl were supported by grants of the German Federal Ministry of Education and Research (BMBF, grant numbers 01GW0710, 01GW0730). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.