Journal article

Mortality related to pharmacotherapies for opioid dependence: a comparative analysis of coronial records

Amy E Gibson, Louisa J Degenhardt

Drug and Alcohol Review | TAYLOR & FRANCIS LTD | Published : 2007


INTRODUCTION AND AIMS: The aim of this study was to compare the mortality associated with oral naltrexone, methadone and buprenorphine in opioid dependence treatment, employing a retrospective data analysis using coronial and prescription data. DESIGN AND METHODS: The number of deaths were identified through national coronial data and number of treatment recipients were estimated from 2000 to 2003 prescriptions and restricted medications data. Mortality rates were expressed as deaths per number of treatment episodes and per person-years at high and low risk of fatal opioid overdose. RESULTS: Thirty-two oral naltrexone, one buprenorphine and 282 methadone-related deaths were identified. Morta..

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