Journal article

Opioid overdose deaths can occur in patients with naltrexone implants

Amy E Gibson, Louisa J Degenhardt, Wayne D Hall

The Medical Journal of Australia | AUSTRALASIAN MED PUBL CO LTD | Published : 2007


From Australian coronial records, we identified five deaths involving implantable naltrexone between 2000 and 2004. One man died from acute narcotism with a naltrexone implant in place and a blood naltrexone level of 0.3 mg/L. A woman died of combined drug effect (including naltrexone) accompanied by severe pain from a naltrexone implant site. These cases indicate that patients can die from opioid overdose with a naltrexone implant and blood naltrexone levels higher than reported blockade levels.