Impact of Morphometry, Myelinization and Synaptic Current Strength on Spike Conduction in Human and Cat Spiral Ganglion Neurons
Frank Rattay, Thomas Potrusil, Cornelia Wenger, Andrew K Wise, Rudolf Glueckert, Anneliese Schrott-Fischer
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2013
BACKGROUND: Our knowledge about the neural code in the auditory nerve is based to a large extent on experiments on cats. Several anatomical differences between auditory neurons in human and cat are expected to lead to functional differences in speed and safety of spike conduction. METHODOLOGY/PRINCIPAL FINDINGS: Confocal microscopy was used to systematically evaluate peripheral and central process diameters, commonness of myelination and morphology of spiral ganglion neurons (SGNs) along the cochlea of three human and three cats. Based on these morphometric data, model analysis reveales that spike conduction in SGNs is characterized by four phases: a postsynaptic delay, constant velocity in ..View full abstract
Awarded by Austrian Science Fund
Awarded by NIDCD
Awarded by Austrian Science Fund (FWF)
This work was supported by the Austrian Science Fund, Grant No. 21848-N13, AK Wise was supported by the NH&MRC and NIDCD grant (HHS-N-263-2007-00053-C). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.