Journal article

Physiology and Molecular Biology of the Relaxin Peptide Family

Ross AD Bathgate, Aaron JW Hsueh, O David Sherwood, JD Neill (ed.)

KNOBIL AND NEILL'S PHYSIOLOGY OF REPRODUCTION, VOLS 1 AND 2, 3RD EDITON | ELSEVIER ACADEMIC PRESS INC | Published : 2006

Abstract

This chapter discusses physiology and molecular biology of the relaxin peptide family. Relaxin-a member of a family of peptide hormones-includes seven members in humans-three relaxin peptides (H1, H2, and H3) and insulin-like peptides (INSL) 3, 4, 5, and 6. All these genes evolved from an ancestral relaxin-3 gene in (lower) vertebrates. The reproductive hormone relaxin is the product of one gene in most species, RLN1. Relaxin-3 is likely an important neuropeptide but has no known roles in reproduction. In contrast, relaxin has vital physiological roles during pregnancy, although its actions vary between species. Hence, relaxin has essential actions on the cervix, pubic symphysis, vagina, ute..

View full abstract