Efficacy of furosemide for prevention of exercise-induced pulmonary hemorrhage in Thoroughbred racehorses
Kenneth W Hinchcliff, Paul S Morley, Alan J Guthrie
Journal of the American Veterinary Medical Association | AMER VETERINARY MEDICAL ASSOC | Published : 2009
OBJECTIVE: To evaluate the efficacy of furosemide for prevention of exercise-induced pulmonary hemorrhage (EIPH) in Thoroughbred racehorses under typical racing conditions. DESIGN: Randomized, placebo-controlled, blinded, crossover field trial. ANIMALS: 167 Thoroughbred racehorses. PROCEDURES: Horses were allocated to race fields of 9 to 16 horses each and raced twice, 1 week apart, with each of the 2 races consisting of the same race field and distance. Each horse received furosemide (500 mg, IV) before one race and a placebo (saline solution) before the other, with the order of treatments randomly determined. Severity of EIPH was scored on a scale from 0 to 4 after each race by means of tr..View full abstract
Supported by the National Horseracing Authority of South Africa, Phumelela Gaming and Leisure (Pty) Ltd, TecMed (Pty) Ltd, Racing South Africa (Pty) Ltd, the Grayson-jockey Club Research Foundation, the Racing Medication and Testing Consortium, the Thoroughbred Racing Trust of South Africa, and private donors.