Journal article

Change in Body Size and Mortality: Results from the Melbourne Collaborative Cohort Study

Amalia Karahalios, Julie A Simpson, Laura Baglietto, Robert J MacInnis, Allison M Hodge, Graham G Giles, Dallas R English

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014

Abstract

BACKGROUND: The association between change in weight or body mass index, and mortality is widely reported, however, both measures fail to account for fat distribution. Change in waist circumference, a measure of central adiposity, in relation to mortality has not been studied extensively. METHODS: We investigated the association between mortality and changes in directly measured waist circumference, hips circumference and weight from baseline (1990-1994) to wave 2 (2003-2007) in a prospective cohort study of people aged 40-69 years at baseline. Cox regression, with age as the time metric and follow-up starting at wave 2, adjusted for confounding variables, was used to estimate hazard ratios ..

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Grants

Awarded by National Health & Medical Research Council (NHMRC)


Awarded by Vic-Health


Awarded by NHMRC Centre of Research Excellence


Funding Acknowledgements

This work was supported by National Health & Medical Research Council (NHMRC) [grant numbers 209057, 251533], Vic-Health (grant number 1998-0406), NHMRC Centre of Research Excellence [grant number 1035261]. Further infrastructure support was provided by the Cancer Council Victoria, and funding was received from the Australian Brewers' Foundation to collect alcohol data in wave 2. AK is funded by an Australian Postgraduate Award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.