Transdermal testosterone improves verbal learning and memory in postmenopausal women not on oestrogen therapy
Susan R Davis, Fiona Jane, Penelope J Robinson, Sonia L Davison, Roisin Worsley, Paul Maruff, Robin J Bell
Clinical Endocrinology | WILEY-BLACKWELL | Published : 2014
OBJECTIVE: The aim of this study was to examine the effects of testosterone on verbal learning and memory in postmenopausal women. DESIGN: Randomized, placebo-controlled trial in which participants were randomized (1:1) to transdermal testosterone gel 300 mcg/day, or identical placebo, for 26 weeks. PATIENTS: Ninety-two postmenopausal women aged 55-65 years, on no systemic sex hormone therapy. MEASUREMENTS: The primary outcome was the score for the International Shopping List Task (ISLT) of CogState. Secondary outcomes included other CogState domains, the Psychological General Well-Being Index (PGWB) and safety variables. RESULTS: Eighty-nine women, median age 60 years, were included in the ..View full abstract
Awarded by Australian NHMRC
This study was supported by a research grant from the Judith Jane Mason and Harold Stannett Williams Memorial Foundation and an unrestricted grant from BioSante pharmaceuticals, who also provided study medication. SR Davis is an Australian NHMRC Principal Research Fellow (Grant No. 1041853). The study sponsor was Monash University. Neither BioSante Pharmaceuticals nor the Judith Jane Mason and Harold Stannett Williams Memorial Foundation had any role in study design, data collection, analysis, interpretation, in the writing of the report or in the decision to submit the paper for publication.