Journal article
Immunity or tolerance? That is the question for dendritic cells
K Shortman, WR Heath
Nature Immunology | NATURE AMERICA INC | Published : 2001
DOI: 10.1038/ni1101-988
Abstract
The “two-signal” model proposes that immature DCs that deliver signal 1 in the absence of signal 2 cross-tolerize CD8+ T cells. New evidence shows that mature DCs are required for both cross-tolerance and cross-priming.