Journal article

Mapping of the region of complement receptor (CR) 1 required for Plasmodium falciparum resetting and demonstration of the importance of CR1 in resetting in field isolates

JA Rowe, SJ Rogerson, A Raza, JM Moulds, MD Kazatchkine, K Marsh, CI Newbold, JP Atkinson, LH Miller

The Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2000


The malaria parasite Plasmodium falciparum induces a number of novel adhesion properties in the erythrocytes that it infects. One of these properties, the ability of infected erythrocytes to bind uninfected erythrocytes to form rosettes, is associated with severe malaria and may play a direct role in the pathogenesis of disease. Previous work has shown that erythrocytes deficient in complement receptor (CR) 1 (CR1, CD35; C3b/C4b receptor) have greatly reduced rosetting capacity, indicating an essential role for CR1 in rosette formation. Using deletion mutants and mAbs, we have localized the region of CR1 required for the formation of P. falciparum rosettes to the area of long homologous repe..

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University of Melbourne Researchers