Journal article

Short Communication: CD4 T Cell Declines Occurring During Suppressive Antiretroviral Therapy Reflect Continued Production of Casp8p41

Nathan W Cummins, Jacqueline Neuhaus, Amy M Sainski, Michael A Strausbauch, Peter J Wettstein, Sharon R Lewin, Montserrat Plana, Stacey A Rizza, Zelalem Temesgen, Giota Touloumi, Matthew Freiberg, James Neaton, Andrew D Badley

AIDS RESEARCH AND HUMAN RETROVIRUSES | MARY ANN LIEBERT, INC | Published : 2014

Abstract

Most patients on suppressive antiretroviral therapy (ART) experience improvements in CD4 T cell count. However, some patients with undetectable viral load continue to lose CD4 T cells for unknown reasons. Casp8p41 is a host-derived protein fragment that is present only in productively infected cells and that causes the death of HIV-infected cells. We questioned whether ongoing CD4(+) T cell losses while on suppressive ART were associated with subclinical HIV replication causing production of Casp8p41. We analyzed the association of Casp8p41 content with subsequent CD4 losses in patients on continuous suppressive ART and in patients who discontinued ART after Casp8p41 content was determined, ..

View full abstract

University of Melbourne Researchers

Grants

Awarded by National Institute of Allergy and Infectious Diseases at the National Institutes of Health (NIH)


Awarded by National Center for Research Resources (NCRR) at the National Institutes of Health (NIH)


Awarded by Medical Research Council


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was supported by the National Institute of Allergy and Infectious Diseases at the National Institutes of Health (grants NIH awards AI40384, U01AI042170, U01AI068641, and U01AI046362). This publication was also made possible by the Mayo Clinic Center for Translational Science Activities (grant UL1 RR024150) from the National Center for Research Resources (NCRR) at the National Institutes of Health (NIH). The complete list of SMART investigators has been previously published. <SUP>13</SUP> We would also like to thank all of the SMART participants.