Advances in chronic obstructive pulmonary disease
CF McDonald, Y Khor
Internal Medicine Journal | WILEY | Published : 2013
Chronic obstructive pulmonary disease (COPD) is characterised by progressive airflow limitation in the presence of identifiable risk factors. Inflammation is the central pathological feature in the pathogenesis of COPD. In addition to its pulmonary effects, COPD is associated with significant extrapulmonary manifestations, including ischaemic heart disease, osteoporosis, stroke and diabetes. Anxiety and depression are also common. Spirometry remains the gold standard diagnostic tool. Pharmacologic and non-pharmacologic therapy can improve symptoms, quality of life and exercise capacity and, through their effects on reducing exacerbations, have the potential to modify disease progression. Bro..View full abstract
Christine McDonald has served on advisory boards for GlaxoSmithKline, Novartis, Pfizer; received conference support from Nycomed; has given presentations at educational meetings sponsored by Boehringer Ingelheim and Novartis.