Selection for complex traits leaves little or no classic signatures of selection
Kathryn E Kemper, Sarah J Saxton, Sunduimijid Bolormaa, Benjamin J Hayes, Michael E Goddard
BMC Genomics | BMC | Published : 2014
BACKGROUND: Selection signatures aim to identify genomic regions underlying recent adaptations in populations. However, the effects of selection in the genome are difficult to distinguish from random processes, such as genetic drift. Often associations between selection signatures and selected variants for complex traits is assumed even though this is rarely (if ever) tested. In this paper, we use 8 breeds of domestic cattle under strong artificial selection to investigate if selection signatures are co-located in genomic regions which are likely to be under selection. RESULTS: Our approaches to identify selection signatures (haplotype heterozygosity, integrated haplotype score and FST) iden..View full abstract
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Awarded by Australian Research Council
Authors thank the Beef Cooperative Research Centre for Beef Genetic Technologies and Dairy Futures Co-operative Research Centre for funding and the provision of data to conduct this research. We thank Gert Nieuwhof from the Australian Dairy Herd Improvement Scheme (ADHIS) for providing the data to create genetic trends in dairy cattle (Additional file 3: Figures S1-S3). This research was supported under Australian Research Council's Discovery Projects funding scheme (project DP1093502). The views expressed herein are those of the authors and are not necessarily those of the Australian Research Council.