Journal article

Quantitative and Functional Diversity of Cross-Reactive EBV-Specific CD8( ) T Cells in a Longitudinal Study Cohort of Lung Transplant Recipients

Nicole A Mifsud, Thi Hoang Oanh Nguyen, Brian D Tait, Tom C Kotsimbos

TRANSPLANTATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010

Abstract

BACKGROUND: Cross-reactive antiviral memory T cells constitute a significant proportion of the alloresponse, potentially playing a pivotal role in adverse posttransplant outcomes in human leukocyte antigen (HLA)-mismatched allografts. We explored the longitudinal dynamics of cross-reactive HLA-B8-restricted Epstein-Barr virus-specific CD8+ T cells directed toward the EBNA3A epitope FLRGRAYGL (FLR) in lung transplant recipients (LTRs) to determine whether their corecognition of HLA-B*4402 expressed on the allograft contributed to poorer posttransplant outcomes. METHODS: Cross-reactive FLR-specific CD8+ T cells were measured in the peripheral blood mononuclear cells and bronchoalveolar lavage ..

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