Quantitative and Functional Diversity of Cross-Reactive EBV-Specific CD8( ) T Cells in a Longitudinal Study Cohort of Lung Transplant Recipients
Nicole A Mifsud, Thi Hoang Oanh Nguyen, Brian D Tait, Tom C Kotsimbos
TRANSPLANTATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010
BACKGROUND: Cross-reactive antiviral memory T cells constitute a significant proportion of the alloresponse, potentially playing a pivotal role in adverse posttransplant outcomes in human leukocyte antigen (HLA)-mismatched allografts. We explored the longitudinal dynamics of cross-reactive HLA-B8-restricted Epstein-Barr virus-specific CD8+ T cells directed toward the EBNA3A epitope FLRGRAYGL (FLR) in lung transplant recipients (LTRs) to determine whether their corecognition of HLA-B*4402 expressed on the allograft contributed to poorer posttransplant outcomes. METHODS: Cross-reactive FLR-specific CD8+ T cells were measured in the peripheral blood mononuclear cells and bronchoalveolar lavage ..View full abstract
This work was supported by the National Health and Medical Research Council of Australia (NHMRC), The Margaret Pratt Foundation, and Peter Doherty NHMRC postdoctoral fellowship (N.A.M.).