Journal article

AUTOANTIBODIES TO SMALL NUCLEAR RIBONUCLEOPROTEINS - A STRONG ASSOCIATION BETWEEN ANTI-SS-B (LA), HLA-B8, AND SJOGRENS SYNDROME

S WHITTINGHAM, IR MACKAY, BD TAIT

AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE | ADIS PRESS AUSTRALASIA P/L | Published : 1983

Abstract

The heterogeneity within multisystem autoimmune disease was evaluated according to the presence of antinuclear antibodies to ribonucleoproteins and the HLA-A1, B8, DR3 phenotype. Patients with various multisystem autoimmune diseases were tested by a highly sensitive radioimmunoassay for autoantibodies to the small nuclear ribonucleoproteins known as SS-B (La) and ribonucleoprotein (RNP), and HLA phenotypes were determined. The 210 patients included 64 with systemic lupus erythematosus (SLE), 11 with "atypical SLE", 41 with Sjögren's syndrome, 22 with mixed connective tissue disease (MCTD), 21 with rheumatoid arthritis (RA), 16 with primary biliary cirrhosis (PBC) and 35 with autoimmune chron..

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