Journal article

HLA AND GM GENES IN SYSTEMIC LUPUS-ERYTHEMATOSUS

S WHITTINGHAM, JD MATHEWS, MS SCHANFIELD, BD TAIT, IR MACKAY

TISSUE ANTIGENS | MUNKSGAARD INT PUBL LTD | Published : 1983

Abstract

HLA and Gm phenotypes were compared in 53 patients with unequivocal systemic lupus erythematosus (SLE) and in 180 healthy subjects. SLE was associated with HLA-B8 (relative risk (RR) = 3.5, P less than 0.001) and with HLA-DR3 (RR = 2.8, P less than 0.01). There was an increased risk of SLE with HLA-B8/B27 (RR = 27.6) and with HLA-B15/B35 (RR greater than 13) and, in contrast, the risk was decreased in subjects with HLA-B40 (RR = 0.3). The risk of SLE in subjects who were heterozygous for the Gm phenotypes a,f,x; b,g was increased (RR = 2.0, P = 0.03) relative to the risk in subjects who were homozygous for these Gm phenotypes. These findings suggest that susceptibility to SLE is influenced b..

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