HLA and alcoholic cirrhosis

Abstract

In fifty‐seven patients with alcoholic cirrhosis the frequency of HLA—DR2 was found to be 47.4%, in contrast to 26.1% in 1 19 normal subjects and 14.0% in 43 cases of autoimmune‐type chronic active hepatitis (CAH). The frequencies of HLA—DR3 in the three respective groups also differed, being 24.6%, 31.9% and 74.4%. The greatly differing HLA—DR profiles in alcoholic cirrhosis and CAH point to immunogenetic differences in predisposition to these two liver diseases. Copyright © 1982, Wiley Blackwell. All rights reserved