Journal article

CROSS-REACTIONS OF IA ANTIGENS BETWEEN MOUSE AND MAN

HA VAUGHAN, MS SANDRIN, IFC MCKENZIE, BD TAIT, A TING

HUMAN IMMUNOLOGY | ELSEVIER SCIENCE INC | Published : 1981

Abstract

Murine alloantisera with specificity for the I-region of the MHC were found to cross-react with human B lymphocytes. By using antisera selected for subregion specificity and including monoclonal antibodies, antisera directed to I-E/Ck products were shown to have the greatest cross-reactivity with human cells. In the reciprocal direction, human anti-DRw alloantisera were also found to contain antibodies that reacted with murine B lymphocytes, and by using congenic strains this reaction was shown to be MHC restricted and was of the "Ia type." By studying appropriate intra-H-2 recombinant strains. The reactivity could be mapped to the 1-E subregion (especially to 1-Ek). In addition, antibodies ..

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