Interaction of HLA and Gm in autoimmune chronic active hepatitis

Abstract

An immunogenetic study of autoimmune chronic active hepatitis (CAH) showed the relative risk (RR) for this disease 11.6 for patients who were HLA-B8, 11.7 for patients who were DR3 and 2.3 for patients who were Gma + X +. Moreover, the Gm haplotype Gma + X + was present in 18 of 40 (45%) patients with HLA-B8, but in none of 10 patients negative for HLA-B8, whereas in 180 healthy controls Gma + X + was evenly distributed among those positive (24%) and negative (18%) for HLA-B8. The RR was lowest in patients lacking HLA-B8 but positive for Gma + X + and twice in subjects who were neither HLA-B8 nor Gma + X +. Statistical analysis indicated that the three-factor effect (disease risk affected by..