Langerhans cells and viral immunity
Anthony L Cunningham, Francis Carbone, Teunis BH Geijtenbeek
European Journal of Immunology | WILEY-V C H VERLAG GMBH | Published : 2008
Langerhans cells (LC) are a unique dendritic cell subset that are located in mucosal stratified squamous epithelium and skin epidermis. Their location is ideally suited for their function as antigen presenting cells that capture invading viruses and induce anti-viral immunity. However, it is becoming evident that the interaction between LC and viruses can result in different responses, depending on the virus and the receptors involved. Here we will discuss the recent data on the similarities and differences in roles of LC in viral immunity to and infection with HIV, herpes simplex and varicella-zoster virus. Although all three viruses interact with LC during initial infection, the effects ca..View full abstract
Awarded by Dutch Scientific Research
We would like to acknowledge the intellectual input from Drs Cheryl Jones, Sem Saeland, Allison Abendroth, Stuart Turville, Lidija Bosnjak, Andrew Harman and Heather Donaghy. We would also like to thank Claire Wolczak for her secretarial assistance. A. L. C. and F. R. C. are supported by program grants from the National Health and Medical Research Council of Australia. T. G. is supported by grants from the Dutch Scientific Research program (NWO. 917-46-367; 912-04-025).