Journal article

Schizophrenia-like psychosis and aceruloplasminemia.

Mark Walterfang, Evrim March, Daniel Varghese, Kathryn Miller, Leonie Simpson, Bruce Tomlinson, Dennis Velakoulis

Neuropsychiatric Disease and Treatment | Published : 2006


Schizophrenia-like illnesses occur in a variety of medical and neurological conditions but to date have not been described in association with aceruloplasminemia. Aceruloplasminemia is an autosomal recessive disorder of iron metabolism which leads to iron deposition in the basal ganglia, thalamus, cerebellum and hippocampus and which usually presents in middle age with extrapyramidal symptoms and dementia. We describe a 21-year-old woman on treatment for aceruloplasminemia who presented with schizophrenia-like psychosis and declining function in the absence of neurological signs. Neuropsychological testing showed significant dominant hemisphere deficits. Magnetic resonance imaging showed bil..

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