Fibroblasts

Abstract

Attempts to ameliorate the contribution of fibroblast remodeling and inflammation in allergy and asthma requires a thorough understanding of proliferation, survival, migration, differentiation, contraction, extracellular matrix synthesis and remodeling, and mediator production. Pharmacologic approaches that have a breadth of impact will need to be targeted to dominant causative cytokines or their common signaling pathways, or be pleiotropic in functionally antagonizing the fibrogenic activities of the fibroblast.