Journal article
Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
A Moayyeri, YH Hsu, D Karasik, K Estrada, SM Xiao, C Nielson, P Srikanth, S Giroux, SG Wilson, HF Zheng, AV Smith, SR Pye, PJ Leo, A Teumer, JY Hwang, C Ohlsson, F McGuigan, RL Minster, C Hayward, JM Olmos Show all
Human Molecular Genetics | Published : 2014
DOI: 10.1093/hmg/ddt675
Abstract
Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n 5 14 260), velocity of sound (VOS; n 5 15 514) and BMD (n 5 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n 5 11 452) and new genotyping in 15 cohorts (de novo n 5 24 902). In combined random effects, meta-analysis of the discovery and replic..
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Awarded by National Institutes of Health
Funding Acknowledgements
This research and the Genetic Factors for Osteoporosis (GEFOS) consortium have been funded by the European Commission (HEALTH-F2-2008-201865-GEFOS). Several other sources of funding and people have supported work in the contributing cohorts as acknowledged in Supplementary Material, Table S2.