Journal article

Factors influencing infection by pandemic influenza A (H1N1)pdm09 over three epidemic waves in Singapore

Mark IC Chen, Alex R Cook, Wei Yen Lim, Raymond Lin, Lin Cui, Ian G Barr, Anne Kelso, Vincent T Chow, Yee Sin Leo, Jung Pu Hsu, Rob Shaw, Serene Chew, Joe Kwan Yap, Meng Chee Phoon, Hiromi WL Koh, Huili Zheng, Linda Tan, Vernon J Lee



INTRODUCTION: Previous influenza pandemics had second and on occasion third waves in many countries that were at times more severe than the initial pandemic waves. OBJECTIVE: This study aims to determine the seroepidemiology of successive waves of H1N1pdm09 infections in Singapore and the overall risks of infection. METHODS: We performed a cohort study amongst 838 adults, with blood samples provided upon recruitment and at 5 points from 2009 to 2011 and tested by haemagglutination inhibition (HI) with A/California/7/2009 (H1N1pdm09). Surveys on key demographic and clinical information were conducted at regular intervals, and associations between seroconversion and these variables were invest..

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University of Melbourne Researchers


Funding Acknowledgements

This project was funded by grants NMRC H1N1-005 and PPG10-09 in Singapore. The WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing. We would also like to acknowledge Nataline Tang Yan Ling, Dollyn Quek Liying and Loh Pei Ling from the National Public Health Laboratory for their contribution towards processing and testing of laboratory samples.