Journal article

Colorectal cancer and self-reported tooth agenesis

Noralane M Lindor, Aung Ko Win, Steven Gallinger, Darshana Daftary, Stephen N Thibodeau, Renato Silva, Ariadne Letra

HEREDITARY CANCER IN CLINICAL PRACTICE | BIOMED CENTRAL LTD | Published : 2014

Abstract

BACKGROUND: Germline mutations in APC and AXIN2 are both associated with colon neoplasia as well as anomalous dental development. We tested the hypothesis that congenitally missing teeth may occur more commonly in individuals diagnosed with colorectal cancer than in individuals without this diagnosis. METHODS: Via a survey conducted on 1636 individuals with colorectal cancer (CRC) and 2788 individuals with no colorectal cancer from the Colon Cancer Family Registry, self-reported information on congenitally missing teeth was collected. The frequency of missing teeth between cases and controls was compared using Pearson's chi-squared test or Fisher's exact test. RESULTS: 4.8% of cases and 5.7%..

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