Journal article

Dopaminergic Haplotype as a Predictor of Spatial Inattention in Children With Attention-Deficit/Hyperactivity Disorder

Mark A Bellgrove, Katherine A Johnson, Edwina Barry, Aisling Mulligan, Ziarah Hawi, Michael Gill, Ian Robertson, Christopher D Chambers

JAMA Psychiatry | AMER MEDICAL ASSOC | Published : 2009

Abstract

CONTEXT: A distinct pattern of selective attention deficits in attention-deficit/hyperactivity disorder (ADHD) has been difficult to identify. Heterogeneity may reflect differences in underlying genetics. OBJECTIVE: To document an objective deficit of selective attention in a large sample of children with and without ADHD using spatial orienting paradigms. By stratifying samples according to the gene dosage of a risk haplotype of the dopamine transporter gene (DAT1), we could determine whether genetic factors predict spatial inattention in ADHD. DESIGN: A case-control design was used. SETTING: Children with ADHD were recruited from clinics or support groups in Ireland. Typically developing c..

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Grants

Funding Acknowledgements

This work was supported by grants from Science Foundation Ireland and the Health Research Board of Ireland. Dr Chambers was supported by a travel grant from the Australian Academy of Science and is currently supported by a BBSRC David Phillips Fellowship. Dr Bellgrove is currently supported by a Career Development Award from the National Health and Medical Research Council of Australia. Dr Johnson is supported by the Health Research Board of Ireland.