Dopaminergic Haplotype as a Predictor of Spatial Inattention in Children With Attention-Deficit/Hyperactivity Disorder
Mark A Bellgrove, Katherine A Johnson, Edwina Barry, Aisling Mulligan, Ziarah Hawi, Michael Gill, Ian Robertson, Christopher D Chambers
JAMA Psychiatry | AMER MEDICAL ASSOC | Published : 2009
CONTEXT: A distinct pattern of selective attention deficits in attention-deficit/hyperactivity disorder (ADHD) has been difficult to identify. Heterogeneity may reflect differences in underlying genetics. OBJECTIVE: To document an objective deficit of selective attention in a large sample of children with and without ADHD using spatial orienting paradigms. By stratifying samples according to the gene dosage of a risk haplotype of the dopamine transporter gene (DAT1), we could determine whether genetic factors predict spatial inattention in ADHD. DESIGN: A case-control design was used. SETTING: Children with ADHD were recruited from clinics or support groups in Ireland. Typically developing c..View full abstract
This work was supported by grants from Science Foundation Ireland and the Health Research Board of Ireland. Dr Chambers was supported by a travel grant from the Australian Academy of Science and is currently supported by a BBSRC David Phillips Fellowship. Dr Bellgrove is currently supported by a Career Development Award from the National Health and Medical Research Council of Australia. Dr Johnson is supported by the Health Research Board of Ireland.