The Relationship between Umbilical Cord Estrogens and Perinatal Characteristics
Martha Hickey, Roger Hart, Jeffrey A Keelan
Cancer Epidemiology Biomarkers & Prevention | AMER ASSOC CANCER RESEARCH | Published : 2014
BACKGROUND: Prenatal estrogen exposure is thought to contribute to later life diseases such as breast cancer. However, few studies have directly measured prenatal estrogens and most have relied on proposed "markers" of estrogen exposure. We used a large population-based birth cohort to directly measure the relationship between prenatal estrogens and perinatal characteristics, including putative markers of estrogen exposure. METHODS: Total estrone (E1), estradiol (E2), estriol (E3), and estetrol (E4) were assayed by liquid chromatography/tandem mass spectrometry from archived mixed arterial and venous serum from 860 umbilical cord blood samples. RESULTS: Values for all estrogens were strongly..View full abstract
This work was funded by a grant from Rotary Mental Health Australia (to M. Hickey). M. Hickey has received an NHMRC Practitioner Fellowship. Core funding for the Western Australian Pregnancy Cohort (Raine) Study was provided by the Raine Medical Research Foundation, The University of Western Australia (UWA), the Faculty of Medicine, Dentistry and Health Sciences at UWA, the Telethon Institute for Child Health Research, the Women's and Infant's Research Foundation, and Curtin University.