Journal article

Navigating the Challenge of Tumor Heterogeneity in Cancer Therapy

Clare Fedele, Richard W Tothill, Grant A McArthur

Cancer Discovery | AMER ASSOC CANCER RESEARCH | Published : 2014

Abstract

The future of cancer treatment lies in personalized strategies designed to specifically target tumorigenic cell populations present in an individual. Although recent advances in directed therapies have greatly improved patient outcomes in some cancers, intuitive drug design is proving more difficult than expected owing largely to the complexity of human cancers. Intratumoral heterogeneity, the presence of multiple genotypically and/or phenotypically distinct cell subpopulations within a single tumor, is a likely cause of drug resistance. Advances in systems biology are helping to unravel the mysteries of cancer progression. In this issue of Cancer Discovery, Zhao and colleagues define a path..

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