Journal article

Enhancement of rat hippocampal long-term potentiation by 17 beta-estradiol involves mitogen-activated protein kinase-dependent and -independent components.

Jin Seuk Kim, Hye Young Kim, Jin Hyuk Kim, Hong Kee Shin, Sang Hun Lee, Yong Sung Lee, Hyeon Son

Neuroscience Letters | Published : 2002


To investigate if estrogen modulates long-term potentiation (LTP) via mitogen-activated protein kinase (MAPK) activation, in vitro hippocampal slices were used to induce LTP through extracellular field recordings. Slices perfused with 17beta-estradiol exhibited a significant enhancement of LTP (224+/-19%) compared with LTP in control slices (157+/-9%). In the presence of PD098059, 17beta-estradiol still produced a significant magnitude of LTP (131+/-7%), revealing the existence of p-MAPK-independent LTP mediated by 17beta-estradiol. Immunocytochemistry showed that 17beta-estradiol promoted a transient increase in nuclear translocation of p-MAPK. 17beta-estradiol induced the extracellular pro..

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